The Mitochondrial Signal Patch™

NAD+ — nicotinamide adenine dinucleotide — is a coenzyme present in every cell in your body. It plays a central role in how your mitochondria convert food into usable energy, how your cells repair damaged DNA, and how efficiently your metabolism functions. The problem is that NAD+ levels decline significantly with age — by some estimates, dropping by more than 50% between your 20s and your 50s. As Dr. Aurora Flemming explains in Chapter 2 of Glow & Thrive, this decline is one of the most predictable and addressable contributors to the energy loss, brain fog, and metabolic slowdown that professional women begin noticing in their mid-30s and 40s. The Mitochondrial Signal Patch™ delivers NAD+ precursors transdermally to support your body's ability to restore and maintain healthier NAD+ levels.

Oral NAD+ supplements — capsules and powders — must pass through your digestive system before reaching your bloodstream. In that process, a significant portion of the active compound is broken down by stomach acid and metabolised by the liver before it reaches your cells. Transdermal delivery bypasses this entirely. The Mitochondrial Signal Patch™ delivers NAD+ precursors directly through the skin into systemic circulation over an 8–12 hour sustained-release window, providing consistent support across your day rather than a single sharp dose. For women dealing with stress-related gut permeability — a common consequence of chronic cortisol elevation — transdermal delivery is an especially meaningful alternative.

Apply one patch each morning to clean, dry skin on the inner wrist, upper hip, or inner arm. Press firmly for 10–15 seconds to ensure full contact. Wear for 8–12 hours, then remove before sleep. Rotate your application site daily to prevent skin sensitivity at any single location. Most women building Dr. Flemming's Glow & Thrive protocol into their morning routine apply the Mitochondrial Signal Patch alongside their Neuro-Reset Patch — one targeting cellular energy infrastructure, the other managing the cortisol environment those cells operate in. Each pack contains 30 patches — a full 30-day supply.

NAD+ restoration is a cumulative process, not an overnight event. What you're supporting is the gradual rebuilding of your cells' energy infrastructure — and that kind of deep cellular change moves at biology's pace, not marketing's pace. Most women report the earliest noticeable shift in afternoon energy stability and mental clarity within the first two weeks. Skin-level changes — improved tone, reduced dullness, the beginning of a more sustained glow — typically become visible after 30–60 days of consistent daily use. Dr. Flemming's Longevity Rebuild Protocol positions the Mitochondrial Signal Patch within a 90-day commitment for this reason. One pack gets you started. The protocol is the full story.

The Mitochondrial Signal Patch™ is designed for external use and general wellness support. It is not a pharmaceutical product and is not intended to diagnose, treat, cure, or prevent any medical condition. NAD+ precursors are generally regarded as well-tolerated, but if you are pregnant, breastfeeding, taking prescription medications — particularly those metabolised by the liver — or managing an active health condition, consult your healthcare provider before starting. If you experience skin irritation at the application site, remove the patch immediately, allow the area to recover, and try an alternative location. Discontinue use and consult a healthcare professional if irritation persists.

The Mitochondrial Signal Patch™ sits within what Dr. Flemming calls the Rebuild Phase of the Glow & Thrive longevity framework — the foundation stage where cellular energy infrastructure is restored before visible skin and metabolic improvements can be sustained. In Chapter 9, Dr. Flemming explains that visible ageing is not primarily a surface problem — it is a cellular energy problem. Slower collagen synthesis, impaired DNA repair, reduced metabolic efficiency: these are downstream consequences of mitochondrial decline. The patch works at that upstream level. If you're implementing the full Longevity Blueprint 90-Day Anti-Ageing System, the Mitochondrial Signal Patch is part of the daily stack from Day 1. If you haven't yet read Glow & Thrive, it provides the complete scientific foundation for why this approach works at the level it does.

They work on different but complementary systems. The Neuro-Reset Patch™ addresses the stress-cortisol loop — the nervous system environment your cells operate in. The Mitochondrial Signal Patch™ addresses the cells themselves — restoring the energy infrastructure that chronic stress depletes over time. Dr. Flemming recommends both as part of her daily stack because the results compound: reducing cortisol burden while simultaneously rebuilding cellular energy capacity produces outcomes that neither patch achieves alone. If you're new to the protocol and starting with one, begin with the Neuro-Reset Patch™ for the first two weeks to stabilise your stress response, then layer in the Mitochondrial Signal Patch™. If you're ready to implement the full system from day one, both can be worn simultaneously — on different application sites.